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Do Night-time Fat Burners Really Work? A Guide To Sleep-Friendly Weight Support

Evidence Based

iHerb has strict sourcing guidelines and draws from peer-reviewed studies, academic research institutions, medical journals, and reputable media sites. This badge indicates that a list of studies, resources, and statistics can be found in the references section at the bottom of the page.

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Sleep And Obesity

As a board-certified physician in obesity medicine, I know that one of the most important aspects to address when evaluating a person with obesity is sleep. In fact, the Obesity Medicine Association lists it as one of its main pillars of weight management.1

This is because inadequate sleep can increase the risk of developing obesity by up to 45%.2In my years working in the health and wellness industry, I have always made sure to address sleep with my clients, especially those who are concerned about their weight.

We learn that increased physical activity will lead to better weight management, so it seems counterintuitive to sleep more. Historically, the message was to “eat less, move more.” According to this thinking, more hours spent awake and moving should lead to a healthier weight. However, that isn’t the case. Sleep is vital because it affects the hormones that regulate appetite and metabolism. Therefore, if you sleep more, you will likely burn more calories during the day and feel less hungry.

Let’s break down how these formulas support weight management, the ingredients that are backed up by evidence, and how to set realistic expectations for your wellness journey.

The Science Of Sleep And Weight Management

To understand how a nighttime supplement works, it's essential to know why sleep matters for your waistline. The relationship between sleep and weight management is well-studied and clear.

When you are sleep-deprived, your body’s metabolic processes become dysfunctional along with your mind. Lack of sleep disrupts several key hunger hormones:3

  • Ghrelin: The "I'm hungry" hormone, which spikes when you are tired.
  • Leptin: The "I'm full" hormone, which decreases when you haven't slept.
  • GLP-1 (stands for glucagon-like peptide): This hormone is all the rage because it is the one targeted by many of the new weight management drugs. However, if you are taking one of these medications, losing sleep is counterproductive because it decreases the body’s natural production of GLP-1, especially in women.4

After a poor night’s sleep, you aren’t craving a salad; you want sugar and carbohydrates. Furthermore, chronic sleep deprivation keeps cortisol (the stress hormone) elevated. High cortisol levels are directly linked to the storage of abdominal fat, which is the worst kind for your health. Speaking of cortisol, it is essential to mention the relationship between stress and weight. Increased stress, anxiety, and depression can lead to a higher number on the scale.5

Therefore, the primary goal of a nighttime weight support formula isn’t just to "burn" calories; it is to optimize the body’s restorative processes so your metabolism can function correctly.

What Are Nighttime Fat Burners?

Nighttime fat burnersare food supplements designed to support both metabolism and relaxation. Conversely, daytime fat burners, which rely heavily on caffeine, yohimbe, or other stimulants to increase thermogenesis (heat production) and energy, take the opposite approach. Furthermore, these stimulant-based fat burners are dangerous and largely ineffective.

Nighttime fat burners are stimulant-free weight support blends intended to:

  • Promote relaxation and deeper sleep
  • Optimize fat oxidation during fasting
  • Regulate cortisol levels
  • Curb late-night cravings

If you aren’t sleeping and feel stressed, your body will think you need to hold onto fat as an emergency energy source. If you sleep well and are more relaxed, your body feels safe to release fat because it doesn’t have to escape a predator (or your boss) suddenly.

Nighttime Fat Burner Ingredients: What To Look For

When looking for a product, you want to see ingredients that are backed by research for both metabolic health and sleep optimisation. Here are some of the most effective ingredients commonly found in high-quality nighttime formulas.

1. Melatonin

Melatoninis naturally produced by the body to signal that it is time to sleep. However, blue light from screens and stress can inhibit this production. Supplemental melatonin helps reset the body’s circadian rhythm.

Research suggests that melatonin may support the production of brown fat (BAT) activity. Unlike white fat (which stores energy), brown fat burns energy to create heat. By supporting healthy sleep patterns and optimal fat ratios, melatonin indirectly improves metabolic dysfunction caused by sleep deprivation.6Notably, melatonin is especially helpful in improving body composition in post-menopausal women.7Most studies have used a dose of 1 to 20 mg per day.6However, higher dosages can alter sleep cycles and cause strange dreams, so it’s best to stick to the lower end of this range.

2. L-Theanine

L-theanineis a naturally occurring amino acid found in green tea and helps promote relaxation without sedation. The effect of L-theanine is described as "calm focus."

L-Theanine helps lower stress-related chemicals in the brain (glutamate) and increases calming chemicals (GABA).8,9Reducing anxiety and promoting a sense of calm helps prevent stress-induced overeating and lowers cortisol spikes that lead to abdominal fat deposition. Studied dosages are around 200 mg daily.10

3. 5-hydroxytryptophan (5-HTP)

5-HTPis a precursor to serotonin, the "feel-good" neurotransmitter. Serotonin regulates mood and plays a role in appetite control.

Low serotonin levels can increase carbohydrate cravings, especially at night. By supporting healthy serotonin levels, 5-HTP can help you say no to that late-night bowl of ice cream. This can help you reduce calorie intake and support a healthy weight.115-HTP also improves sleep quality. Doses that enhance sleep and promote weight management are typically 100-200 mg taken at night.12

4. Green Tea Extract (Decaffeinated)

Green tea extractis added to many weight-management supplements, primarily because of a catechin called EGCG (Epigallocatechin gallate).

EGCG is a powerhouse antioxidant known to support fat oxidation (the breakdown of fat). In daytime formulas, this is often paired with caffeine. However, in a nighttime fat burner, you will typically find a decaffeinated extract. This allows you to get the metabolic benefits of green tea antioxidants without keeping you awake. The dose of EGCG should not exceed 300 mg daily, because there are some concerns about liver toxicity.13

5. L-Carnitine

L-Carnitineis an amino acid derivative that is involved in energy production. It transports fatty acids into your cells' mitochondria, where they are burned for energy. Mitochondria are the cell’s “powerhouse.”

While often used by athletes for performance, L-carnitine helps the body use fat stores for fuel while you fast (or sleep). It supports the body's natural repair and recovery processes.14The optimal dose for weight management is between 1 and 3 grams per day, especially when combined with lifestyle interventions like diet and exercise.15

Do Fat Burners Work While You Sleep?

A good nighttime fat burner provides benefits beyond fat burning:

  • Better sleep quality: Falling asleep more easily, waking up less, and feeling more refreshed in the morning
  • Less stress: Feeling more relaxed instead of wired and restless
  • Fewer late-night cravings: Less mindless snacking

All of these make it easier to maintain balanced eating and activity levels throughout the day, as well as balance hormones, which can help with weight management.

Who Should Consider Nighttime Support?

While anyone looking to optimize their health can benefit from better sleep, these supplements are particularly beneficial for specific groups:

  • The "Wired and Tired": If you have trouble getting to sleep due to stress and suffer from fatigue during the day, a nighttime sleep supplement might be helpful for you.
  • Women Over 30 and Perimenopause: A fat burner for women, specifically used during nighttime, can help manage the unique sleep disturbances and weight creep associated with hormonal changes.
  • Late-Night Snackers: If your diet falls apart at 9:00 PM, ingredients like 5-HTP can help you avoid the late-night cravings (and go to bed earlier).
  • Those Sensitive to Stimulants: Many people cannot tolerate the high caffeine content of daytime thermogenic fatburners. Also, these supplements can be dangerous and cause many side effects. Nighttime formulas offer a non-stimulant alternative.

How To Choose A Quality Supplement

When shopping for a clean, effective product, keep these criteria in mind:

1. Check the "Other Ingredients."

You want a clean-label product. Avoid supplements that contain artificial fillers, excessive dyes, or preservatives. The supplement should contain the active ingredients and little else.

2. Verify It Is Stimulant-Free

Double-check the label for hidden sources of caffeine (like guarana or tea extracts).

3. Look for Clinical Dosages

  • Check whether the amounts of ingredients (L-carnitine, green tea extract, melatonin, L-theanine, 5-HTP) are within typical ranges used in studies.
  • Be cautious with vague “proprietary blends” that list total milligrams but don’t show how much of each ingredient is included.

4. Third Party Testing

Reputable brands often test their products for purity and potency. This ensures that what is on the label is in the bottle.

When To Skip Nighttime Fat Burners

There are times when a nighttime fat burner isn’t the right choice. Avoid them if:

  • You take multiple sleep medicines or sedating supplements. This will avoid an interaction.
  • You have severe health conditions, particularly mood disorders, autoimmune disease, or uncontrolled medical issues. Discuss all supplement and diet changes with your clinician.
  • You use medicines that affect serotonin (certain antidepressants), which may interact with 5-HTP.
  • You are pregnant, breastfeeding, or actively trying to conceive

The Verdict

Can you burn fat while you sleep? Nighttime fat burners can help with weight management and help you avoid stimulants. They can also work with your hormones to improve satiety and help you avoid cravings. Prioritizing sleep and managing stress can improve the balance of metabolic hormones that control weight, and even enhance the way certain weight-loss drugs work.

If you are struggling with cravings, stress, or stubborn weight that won’t budge despite your best efforts, a stimulant-free nighttime formula might help you get the sleep you need and make weight management easier.

Ready to improve your sleep and support your metabolism? Browse our selection of premium, science-backed nighttime support supplements.

Note: This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a healthcare professional before starting any new supplement regimen.

References:

  1. Frequently Asked Questions about Sleep, Stress, and Obesity. Obesity Medicine Association. Accessed November 21, 2025. https://obesitymedicine.org/blog/frequently-asked-questions-about-sleep-stress-and-obesity/
  2. Tubbs AS, Khader W, Fernandez F, Grandner MA. The common denominators of sleep, obesity, and psychopathology. Curr Opin Psychol. 2020;34:84-88. doi:10.1016/j.copsyc.2019.11.003
  3. Taheri S, Lin L, Austin D, Young T, Mignot E. Short sleep duration is associ ated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 2004;1(3):e62. doi:10.1371/journal.pmed.0010062
  4. St-Onge MP, O’Keeffe M, Roberts AL, RoyChoudhury A, Laferrère B. Short sleep duration, glucose dysregulation and hormonal regulation of appetite in men and women. Sleep. 2012;35(11):1503-1510. doi:10.5665/sleep.2198
  5. Geiker NRW, Astrup A, Hjorth MF, Sjödin A, Pijls L, Markus CR. Does stress influence sleep patterns, food intake, weight gain, abdominal obesity, and weight loss interventions, and vice versa? Obes Rev. 2018;19(1):81-97. doi:10.1111/obr.12603
  6. Genario R, Cipolla-Neto J, Bueno AA, Santos HO. Melatonin supplementation in the management of obesity and obesity-associated disorders: A review of physiological mechanisms and clinical applications. Pharmacol Res. 2021;163:105254. doi:10.1016/j.phrs.2020.105254
  7. Amstrup AK, Sikjaer T, Pedersen SB, Heickendorff L, Mosekilde L, Rejnmark L. Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women: A randomised placebo-controlled trial. Clin Endocrinol (Oxf). 2016;84(3):342-347. doi:10.1111/cen 12942
  8. Conti F. Dietary Protocols to Promote and Improve Restful Sleep: A Narrative Review. Nutr Rev. Published online May 26, 2025:nuaf062. doi:10.1093/nutrit/nuaf062
  9. Lardner AL. Neurobiological effects of the green tea constituent theanine and its potential role in the treatment of psychiatric and neurodegenerative disorders. Nutr Neurosci. 2014;17(4):145-155. doi:10.1179/1476830513Y.0000000079
  10. Hidese S, Ogawa S, Ota M, et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019;11(10):2362. doi:10.3390/nu11102362
  11. Cangiano C, Ceci F, Cascino A, et al. Eating behaviour and adherence to food prescriptions in obese adult subjects treated with 5-hydroxytryptophan (5-HTP). Am J Clin Nutr. 1992;56(5):863-867. doi:10.1093/ajcn/56.5.863
  12. Evans C, Mekhail V, Curtis J, et al. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT. J Diet Suppl. 2023;20(4):621-630. doi:10.1080/19390211.2022.2076760
  13. Mah E, Chen O, Liska DJ, Blumberg JB. Food Supplements for Weight Management: A Narrative Review of Safety and Metabolic Health Benefits. Nutrients. 2022;14(9):1787. doi:10.3390/nu14091787
  14. Talenezhad N, Mohammadi M, Ramezani-Jolfaie N, Mozaffari-Khosravi H, Salehi-Abargouei A. Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomised controlled clinical trials with dose-response analysis. Clin Nutr ESPEN. 2020;37:9-23. doi:10.1016/j.clnesp.2020.03.008
  15. Pooyandjoo M, Nouhi M, Shab-Bidar S, Djafarian K, Olyaeemanesh A. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomised controlled trials. Obes Rev. 2016;17(10):970-976. doi:10.1111/obr.12436

DISCLAIMER:This Wellness Hub does not intend to provide diagnosis... Read More

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